Characterization of diterpene metabolism in rats with ingestion of seed products from Euphorbia lathyris L. (Semen Euphorbiae and Semen Euphorbiae Pulveratum) using UHPLC-Q-Exactive MS

Previous pharmacological studies have indicated that diterpenoids are the primary effective chemical cluster in the seeds of Euphorbia lathyris L. The seed products are used in traditional Chinese medicine in the forms of Semen Euphorbiae (SE) and Semen Euphorbiae Pulveratum (SEP). However, the metabolism of the plant's diterpenoids has not been well elucidated, which means that the in vivo metabolite products have not been identified. The current study screened the physiological metabolites of six diterpenes [Euphorbia factor L₁ (L1), L₂ (L2), L₃ (L3), L_7a (L7a), L_7b (L7b), and L₈ (L8)] in feces and urine of rats after oral administration of SE and SEP using UHPLC-Q-Exactive MS. A total of 22 metabolites were detected in feces and 8 in urine, indicating that the major elimination route of diterpenoids is via the colon. Hydrolysis, methylation, and glucuronidation served as the primary metabolic pathways of these diterpenoids. In sum, this study contributed to the elucidation of new metabolites and metabolic pathways of SE and SEP, and the new chemical identities can be used to guide further pharmacokinetic studies.     

Effect of Cs(I) and Cr(III) on the adsorption of strontium ion by living irradiated Saccharomyces cerevisiae

Journal of Radioanalytical and Nuclear Chemistry - In this paper, the effects of three coexisting ion systems (Cs, Sr), (Cr, Sr) and (Cs, Cr, Sr) on the adsorption of Sr(II) by irradiated...     

Dye Sensitization Offers a Brighter Afterglow Nanoparticle Future for in vivo Recharged Luminescent Imaging

While concerns about improving recharged afterglow intensity in vivo still motivate further exploration, afterglow nanoparticles (AGNP) offer unique optical merit for autofluorescence-free biological imaging. Apart from efforts enhancing the afterglow emission properties of AGNP, improving afterglow excitation response to visible or near infrared light is important but has lacked success. Dye sensitization has been used to improve the optical response of photovoltaic nanomaterials and to enhance upconversion luminescence efficiency. This concept has recently been expanded and applied to AGNPs. As a new multifunctional nanoprobe, such dye-sensitized AGNP takes advantage of both high spatial resolution fluorescence imaging and sensitive afterglow imaging. This Concept introduces the background, the concept, mechanism, and related imaging application, as well as reviewing existing challenges and proposing future developmental directions for the dye-sensitized AGNPs.     

Chemical Constituents of Selaginella moellendorffii

Chemistry of Natural Compounds -     

Templated synthesis and assembly with sustainable cellulose nanomaterial for functional nanostructure

Cellulose - Templated synthesis and assembly for nanostructured materials with tailored properties have received considerable attention. The powerful templates with predefined structures can guide...     

Acridone-Based Host Materials for Green Phosphorescent and Thermally Activated Delayed Fluorescent OLEDs with Low-Efficiency Roll-Offs

By linking the carbazole unit to the nitrogen atom of acridone through phenyl or pyridyl, two compounds, named 10-(4-(9H-carbazol-9-yl)phenyl)acridin-9(10H)-one (AC-Ph-Cz) and 10-(5-(9H-carbazol-9-yl)pyridin-2-yl)acridin-9(10H)-one (AC-Py-Cz) were designed and synthesized. These two materials, characterized with highly twisted and rigid structure, good thermal stability, and balanced carrier-transporting properties, were employed as host materials for green phosphorescent and thermally activated delayed fluorescent organic light-emitting diodes (OLEDs). The carbazole group, despite its small contribution to the highest occupied molecular orbitals (HOMOs) of these two materials, plays an essential role as an intramolecular host in energy delivering and improving the hole transporting ability of these two hosts. The incorporation of the electron-deficient pyridyl group as a linking group slightly improves the electron transporting capability of AC-Py-Cz. The green phosphorescent OLED (PhOLED) based on AC-Py-Cz exhibited excellent device performance with a turn-on voltage of 2.5 V, a maximum power efficiency and an external quantum efficiency (η_ext) of 89.8 lm W⁻¹ and 25.2 %, respectively, benefitting from the better charge-balancing ability of AC-Py-Cz host due to the presence of the pyridyl bridge. More importantly, all the devices based on these two hosts showed low efficiency roll-off at high brightness due to the suppressed non-radiative transition in the emitting layer. In particular, the AC-Py-Cz-hosted green PhOLED exhibited an efficiency roll-off of 1.6 % from the maximum next at a high brightness of 1000 cd m⁻² and a roll-off of 15.9 % at an extremely high brightness of 10000 cd m⁻². This study manifests that acridone-based host materials have great potential in fabricating OLEDs with low efficiency roll-off.     

Excellent UV-absorbing cotton fabric with high durability and hydrophobicity based on surface-initiated ATRP of polymerizable organic UV-absorber

Cellulose - Ultraviolet (UV) protective cotton fabric is a convenient and reliable way to protect human body from sunlight. Herein, a polymerizable UV-absorber,...     

新型BT-BMT-xBNT无铅高储能密度陶瓷研究

本文采用传统固相反应法,成功制备了新型无铅弛豫铁电陶瓷(1-x)[0.9BaTiO₃-0.1Bi(Mg_0.25Ta_0.5)O₃]-xBi_0.5Na_0.5TiO₃。结果表明,较高居里温度的Bi_0.5Na_0.5TiO₃的引入,使得材料体系中建立了更多的以Bi—O耦合为主的极性纳米区域,弥补了因Bi(Mg_0.25Ta_0.5)O₃的加入导致的宏观极化强度的减少,提高了材料的饱和极化强度,实现了较高储能密度的同时具有更好的温度稳定性。在245 kV/cm电场强度下,x=0.2样品的储能密度约为4.01 J/cm³,储能效率约为84.86%,同时该组分在20~170 ℃储能密度的变化率小于5%,储能效率的变化率小于6%,表现出优异的温度稳定性。     

Classify the Higgs decays with the PFN and ParticleNet at electron–positron colliders

Various Higgs factories are proposed to study the Higgs boson precisely and systematically in a model- independent way. In this study, the Particle Flow Network and ParticleNet techniques are used to classify the Higgs decays into multicategories, and the ultimate goal is to realize an "end-to-end" analysis. A Monte Carlo simulation study is performed to demonstrate the feasibility, and the performance looks rather promising. This result could be the basis of a "one-stop" analysis to measure all the branching fractions of the Higgs decays simultaneously.     

新型多孔材料用作色谱手性固定相

手性固定相是色谱法分离分析手性化合物的关键。近年来,随着材料科学的迅速发展,越来越多的新型手性材料被作为色谱固定相用于手性分离分析。本文综述了近5年来液相色谱、气相色谱和毛细管电色谱领域的新型手性固定相的研究进展,重点总结了基于手性多孔材料的新型手性固定相研究,最后对手性固定相的研究进行了总结与展望。